remhq.com: The film documents a seven day tour of Nebraska, Iowa, Illinois, Indiana, Ohio, Kentucky, and Tennessee by one rock star (Bono), two movie stars (Chris Tucker and Ashley Judd), one heroic Ugandan activist (Agnes Nyamayarwo), three brilliant doctors, and twelve talented Ghanian kids who travelled in three buses through "the heart of America" in order to put a human face on the HIV/AIDS crisis.

The seven days on the road that this movie captures and presents, from the campaign-like schedule of private meetings and public events, to the quiet moments of reverie it captures Bono, Agnes, and others in, are the beginning of a movement, that, as Bono tells a group of college students, "will change the world." In fact it did change the world.

As a result of the tour, thousands of conscientious Americans called the White House in December 2002 to request an "historic AIDS initiative" (6,500 Africans die of HIV/AIDS each day and another 9,500 are infected with the disease), and in response in the 2003 State of the Union the President proposed just such a plan, since enjoying bipartisan support in the Congress. This was the doing of people in the "heart of America," which beats throughout this documentary.